Description
Catalogue Number	111609
Synonyms	Embedding agents for microscopy, Embedding agent, Histosec®
Description	HISTOSEC PASTILLES SOLIDIFICATION POINT
Overview	Histosec® pastilles is an embedding medium for histology of samples of human origin. It is a paraffin enriched with polymers, also available without the addition of DMSO (dimethyl sulfoxide). DMSO increases the rate of penetration of paraffin and provides additional preservation of the tissue structures. Its melting range is between 56 - 58 °C and, within this range any specimen can be processed without fear of damage irrespective of the method used. In most clinical laboratories the paraffinization is performed with an automated embedding system and is performed directly after the histoprocessing. The Histosec® pastilles are well soluble with the Intermedia Xylene or xylene substitutes (such as Neo-Clear(R)). The paraffin is an IVD registered product and CE certified, thus can be used for clinical diagnostic purposes.

Product Information
HS Code	2712 20 90

Physicochemical Information
Flash point	>100 °C
Bulk density	400 kg/m3

Toxicological Information
LD 50 dermal	LD50 Rabbit > 3000 mg/kg

Safety Information according to GHS
Storage class	10 - 13 Other liquids and solids
WGK	NWG not water endangering
Disposal	3 Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.

Storage and Shipping Information
Storage	Store at +15°C to +25°C.

Specifications
Solidification point (rotating thermometer method)	56 - 58 °C
Effect of heating (at 60 °C/100 g)	clear melt within max. 20 hours
Solubility in xylene (at 20 °C/0.1 g in 5 ml)	clear solute within max. 20 hours
Cutting results (4 µm slices)	conforms
Solubility of slices in xylene	< 50 seconds

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MERCK 111609 Histosec pastilles solidification point 56-58°C embedding agent for histology

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